Stefan Rödiger (@pangolin)

Prof. & Researcher focused on #Bioanalytics, #Bioinformatics, #Pharma, Human #diagnostics (#LiquidBiopsy) and a bit #Forensics

Joined: 06 Jun 2025
Website: www.b-tu.de/en/fg-multiparameterdiagnostik/rg-roediger
ORCID: Verified link 0000-0002-1441-6512
Also on: @RoedigerRG@social.anoxinon.de

Stefan Rödiger boosted

Hacker News

@hkrn@mstdn.social last yr.

Huntington's disease treated for first time
L: https://www.bbc.com/news/articles/cevz13xkxpro
C: https://news.ycombinator.com/item?id=45358940
posted on 2025.09.24 at 07:37:30 (c=0, p=5)

Huntington's disease treated for first time | Hacker News

1 more link(s)

Stefan Rödiger boosted

DFG

@dfg_public@wisskomm.social last yr.

Hurra und Gratulation! 👏🏆 Alle vier Gewinner*innen unseres #Europapreis‘ 2025 wurden beim EU Contest for Young Scientists #EUCYS in Riga ausgezeichnet. Ein toller Erfolg für "Team Germany"!!!

Alle Einzelheiten zu den Preisen und Projekten der Jungforscher*innen:
👉 https://www.dfg.de/de/service/presse/pressemitteilungen/2025/pressemitteilung-nr-29

Die erfolgreichen EUCYS-Teilnehmer*innen freuen sich vor der Fotowand des Wettbewerbs.

Alle vier Europa-Preisträger*innen der DFG auch beim European Union Contest for Young Scientists in Riga erfolgreich

Stefan Rödiger

@pangolin last yr.

"As of 2026, Sorbonne University will no longer submit data to the Times Higher Education (THE) World University Rankings. The decision comes as part of a wider approach to promote open science and reform research assessment, in accordance with the university’s commitment to the CoARA Agreement and the Barcelona Declaration. Sorbonne University is choosing open and transparent databases to assess its academic performance."

sorbonne-universite.fr/en/ne...

#CoARA #TimesHigherEducation #OpenScience #Sorbonne

Press release of the Sorbonne University 🇫🇷 withdraws from THE rankings (PDF)

1 more link(s)

Stefan Rödiger boosted

eLife

@eLife@fediscience.org last yr.

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
https://elifesciences.org/articles/105496?utm_source=mastodon&utm_medium=social&utm_campaign=organic_assessment

eLife

Molecular architecture of thylakoid membranes within intact spinach chloroplasts

Cryo-electron tomography reveals plant photosynthetic membranes with single-complex precision, supporting a simple two-domain model of membrane organization.

Stefan Rödiger boosted

Rainer Mühlhoff

@RainerMuehlhoff@chaos.social last yr.

Great news 🎉🌟📝🚀: Die DFG hat unser Projekt "Prädiktives Wissen ist Macht: Ethik und Recht kollektiver Privatheit in der Datengesellschaft" bewilligt! (mit @HannahRuschemeier )

Wir untersuchen aus ethischer und rechtlicher Perspektive die gesellschaftstrukturellen Gefahren prädiktiver KI-Anwendungen im Sinne normativer, kritischer Grundlagenforschung.

https://rainermuehlhoff.de/DFG-project-predictive-knowledge/

@dfg_public

Rainer Mühlhoff

Unser interdisziplinäres Forschungsprojekt „Prädiktives Wissen ist Macht: Ethik und Recht kollektiver Privatheit in der Datengesellschaft“ (mit Prof. Dr. Hannah Ruschemeier) wird für die nächsten drei Jahre von der DFG gefördert.

Rainer Mühlhoff

@RainerMuehlhoff@chaos.social last yr.

Great news 🎉🌟📝🚀: Die DFG hat unser Projekt "Prädiktives Wissen ist Macht: Ethik und Recht kollektiver Privatheit in der Datengesellschaft" bewilligt! (mit @HannahRuschemeier )

Wir untersuchen aus ethischer und rechtlicher Perspektive die gesellschaftstrukturellen Gefahren prädiktiver KI-Anwendungen im Sinne normativer, kritischer Grundlagenforschung.

https://rainermuehlhoff.de/DFG-project-predictive-knowledge/

@dfg_public

Rainer Mühlhoff

Stefan Rödiger

@pangolin last yr.

@RainerMuehlhoff@chaos.social @dfg_public@wisskomm.social @HannahRuschemeier@fediscience.org

💪

Welche rechtlichen Aspekte werden Gegenstand sein?

Bei den #Medienrechtstagen an der #BTU_CS befassen wir uns dieses Jahr auch mit einigen Themen zu KI, elektronische Akten und den EU AI Act – mit Fokus auf Gerechtigkeit, Datenschutz und rechtskonforme Umsetzung..

b-tu.de/news/artikel/29132-c...

#AIAct #Recht #KI

BTU Cottbus-Senftenberg

Künstliche Intelligenz und Digitalisierung im Recht

Digitalisierung und KI trifft Justiz: Die Cottbuser Medienrechtstage beleuchten Chancen und Herausforderungen rund um KI, elektronische Akten und den EU AI Act – mit Fokus auf Gerechtigkeit, Datenschutz und rechtskonforme Umsetzung.

Stefan Rödiger boosted

Akademy

@akademy@floss.social last yr.

Meanwhile, would you like to help us organize #Akademy2026? The Call for Hosts is open. Send us your proposal... But be quick! Deadline for reception of proposals is Oct 1st.

More info: https://akademy.kde.org/news/2025-07_akademy-2026-call-for-hosts/

#KDE #FOSS #OpenSource #FreeSoftware #events

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Akademy

Akademy 2026 Call for Hosts

One of the biggest things you can do for KDE (that does not involve coding) is helping us organize Akademy. In 2026, we are organizing a special edition of Akademy to celebrate KDE's 30th birthday. We want to make this occasion memorable by celebrating this important milestone with Akademy. The birthday edition of Akademy will not only bring together contributors, users, and partners but will also reflect on three decades of community, collaboration, innovation, and Free Software.

Stefan Rödiger boosted

Akademy

@akademy@floss.social last yr.

The full report of what happened at #Akademy2025 is now live. Includes full descriptions of all the talks and never before seen pictures (?) of people giving talks!

https://akademy.kde.org/news/2025-09_akademy-2025-report/

Videos coming soon!

#KDE #FOSS #OpenSource #FreeSoftware #events

Akademy

Akademy 2025 - KDE at a Turning Point

Akademy 2025 group photo. This year's Akademy took place in Berlin, Germany. The city's modernity and avant-garde counterculture atmosphere fit very well with the current mood in the KDE community. As volunteer developers push forward with technologies that even multi-billion dollar corporations struggle to imitate, there is a general feeling that something great is on the horizon. With major migrations and potential adoptions in public administrations, not to mention KDE technologies making their way into all kinds of devices, it seems that we are finally on the verge of going mainstream and bringing FLOSS to the general public.

See full thread

Le Néandertal se sent las, las

@HydrePrever@mathstodon.xyz last yr.

@pangolin thank you for this nice summary.

Stefan Rödiger

@pangolin last yr.

I hope it is a bit of help for you. Do you have a link to your package?

Le Néandertal se sent las, las

@HydrePrever@mathstodon.xyz last yr.

Remote activity:

Stefan Rödiger

@pangolin last yr.

Academic musings about licences

@HydrePrever@mathstodon.xyz To be honest, it is not possible to answer your question.

What is your aim? Your decision finally reflects more or less a balance between philosophical open source ideals, practicalities regarding package dependencies, and your personal or institutional goals for code sharing.

Here is my academic insight.

These licenses are legal contracts. Choosing a license for an R package depends on how much control and openness is desired for the code, compatibility with dependencies, and philosophical stance about software freedom vs. permissiveness. You are right, the most common licenses on CRAN are MIT, BSD‑3, GPL‑2/3, Apache 2.0, MPL 2.0.

For example the GPL-3 is a strong copyleft license, meaning any derivative works must also be licensed under the GPL. In contrast, the MPL 2.0 is a weak copyleft license, since only the modified files must remain under MPL, while rest can stay proprietary. It guarantees freedom for users to share, modify, and distribute modified versions, but all such derivatives must also be open-sourced under the same terms. If the package links (statically or dynamically) to other GPL-licensed software, it almost always needs to be GPL as well. The viral nature of the GPL means it enforces openness, which some see as a benefit for building a truly open ecosystem, but others view as restrictive if they want their code used in closed or commercial contexts. If maximizing openness and ensuring all derivatives remain open source is important, GPL-3 is the best fit.

In contrast, The MIT (and BSD-3) license is simple most common and highly permissive ("least friction"). It lets anyone use, copy, modify, merge, publish, distribute, sublicense, and sell copies of the software, as long as the original copyright and license notice remain. MIT is well liked for its simplicity and minimal restriction, making it a go-to for developers who want the broadest adoption with the least friction. Importantly, MIT-licensed code can be re-used in both open and closed source projects. For maximally broad reuse, minimal restrictions, and commercial friendliness, MIT is generally preferred. IIRC, Apache 2.0 is also permissive with an explicit patent grant, and it includes a clause that protects against contributor lawsuits. But I am not so sure about this.

CC0 ("No Rights Reserved") is basically a public domain dedication for the code (rare on CRAN), waiving as many rights as legally possible. ImageJ is not CC0 but public domain. This app became the defacto standard for many doing image analysis. It’s ideal for pure data packages or code that the author wants to be maximally reused without even attribution. However, it is less common for code and may cause confusion, as many open source projects and organizations are more familiar with MIT or GPL. For pure data or works intended to be fully in public domain, CC0 is appropriate.

Other licenses include Apache 2.0, BSD, MPL or even more restrictive proprietary licenses. Each comes with its own nuances, such as patent clauses (Apache) or specific attribution requirements (BSD). CRAN policies generally expect open source licenses, and proprietary licenses are not accepted for public packages.

I have MIT and GPL licensed packages on CRAN, and I am fine with both.

Stefan Rödiger boosted

Kris

@isotopp@infosec.exchange last yr.

Happy Linux Day, to those who celebrate.

Linux v0.01 was uploaded on 17-Sep 1991.

https://lkml.iu.edu/hypermail/linux/kernel/2109.2/03485.html

Linux-Kernel Archive: 30 years since the Linux 0.01 release

Stefan Rödiger boosted

DFG

@dfg_public@wisskomm.social last yr.

@lukasfx Danke für den Kommentar, den wir auch gerne an die Fachabteilung weitergegeben haben.
Tatsächlich sieht die DFG auch die vielfältigen Herausforderungen der Publikationspraxis und bearbeitet diese auf mehreren Ebenen, z.B. durch den Auf-/Ausbau wissenschaftsgeleiteter Open-Access-Infrastrukturen oder des Publikationsmodells Diamond OA. Bei der DFG-Positionierung zum wissenschaftl. Publizieren finden sich noch mehr Hintergrund- und weiterführende Infos zum Thema:
https://fcld.ly/position

Stefan Rödiger boosted

DFG

@dfg_public@wisskomm.social last yr.

#Wisskomm nicht als Publikation in Büchern oder Fachzeitschriften, sondern als Fach-, Daten- und Software-Repositorien oder Blog? Das geht natürlich! Doch auch dann sollte die #WissenschaftlicheIntegritaet berücksichtigt werden. Hinweise dazu hat die Leitlinie 15 der "Guten wissenschaftlichen Praxis" – mit immer mehr Beispielen aus der Praxis. Neu: Ein Kommentar zu Erscheinungsformen unseriöser Publikationsorte:
https://fcld.ly/ll15

Stefan Rödiger boosted

Die Forschende Hochschule Hof

@HomeOfResearch@wisskomm.social last yr.

🕵️♂️ How anonymous is anonymous?
In his PhD, Dr. Sebastian Pahl studied the security of the Tor network, uncovering weaknesses but also ways to improve anonymity & performance.

The research was a collaboration between Hof University and the University of Luxembourg, supervised by Prof. Dr. Florian Adamsky. 🌐🔐

🔗 https://t1p.de/se6tq

#dieforschendehochschulehof #hierwirdknallhartgeforscht #ScienceMastodon #CyberSecurity #Tor #Research #AnonymityOnline #Anonymous

2 media files

Alice visits a website about Tor…; Source: Hof University of Applied Sciences;

Dr. Sebastian Pahl; Source: Hof University of Applied Sciences;

Campuls

How anonymous is anonymous? Sebastian Pahl on security in the Tor network - Campuls

In his doctoral thesis, Dr. Sebastian Pahl investigated how secure anonymous communication on the internet really is. His focus was on the Tor network - a system that helps people to protect their identity online.

Stefan Rödiger boosted

last yr.

AI Scientist-v2 Passes ICLR Peer Review Workshop

AI Scientist-v2 makes history as the first automated research system to pass ICLR peer review with above-average human scores.

Unknown

AI Scientist-v2 Passes ICLR Peer Review Workshop

Stefan Rödiger boosted

The Transmitter

@thetransmitter@mastodon.social last yr.

The first nerve net connectome is here, and it belongs to a comb jelly. This ancient lineage could crack open research into the evolution of sensory motor coordination, researchers say.

By Siddhant Pusdekar

https://www.thetransmitter.org/connectome/first-nerve-net-connectome-shows-how-evolutionarily-ancient-nervous-system-coordinates-movement/?utm_source=mastodon&utm_medium=org-social&utm_campaign=20250916-news-first-nerve-net-connectome

https://www.thetransmitter.org

First nerve-net connectome shows how evolutionarily ancient nervous system coordinates movement

Stefan Rödiger boosted

Stefan Rödiger

@pangolin last yr.

DGKM in Landshut

During the past few days I was at the DGKMH conference in Landshut – what a nice event! 🎉 2025 | 12. - 13. September 43. Jahrestagung der Deutschen Gesellschaft für klinische Mikrozirkulation und Hämorheologie e.V. Next one is in Passau (Germany). With such an…

Stefan Rödiger

Landshut with view on the the Cathedral of St. Martin with its bell tower

2 media files

This research investigates different methods – covalent and non-covalent (streptavidin-biotin) coupling – for attaching capture probes to microbeads used in miRNA detection assays. The key finding is that the non-covalent method yields smoother melting curves and significantly higher hybridization efficiency (90% vs 60% for covalent binding). This seemingly technical detail has important implications for developing robust and reliable bioanalytical tests, particularly those targeting microRNAs as biomarkers for neurodegenerative diseases or other conditions.

The variability observed in the covalent coupling method, likely due to secondary amines on the oligonucleotides affecting melting behavior, introduces potential inconsistencies in test results. Smoother melting curves achieved with non-covalent coupling suggest more consistent and predictable binding of target miRNAs to the microbeads. This translates directly into improved analytical sensitivity – meaning the ability to detect even low concentrations of miRNA biomarkers – and greater accuracy in quantification.

For bioanalytical tests intended for clinical diagnostics or biomedical research, these improvements are crucial. Reliable detection of subtle changes in miRNA levels can be vital for early disease diagnosis, monitoring treatment response, or understanding disease progression. By optimizing the immobilization strategy on microbeads to ensure efficient and consistent hybridization, this study contributes to developing more dependable and sensitive bioanalytical tools that can ultimately advance our ability to diagnose and manage a wide range of diseases. — This research investigates different methods – covalent and non-covalent (streptavidin-biotin) coupling – for attaching capture probes to microbeads used in miRNA detection assays. The key finding is that the non-covalent method yields smoother melting curves and significantly higher hybridization efficiency (90% vs 60% for covalent binding). This seemingly technical detail has important implications for developing robust and reliable bioanalytical tests, particularly those targeting microRNAs as biomarkers for neurodegenerative diseases or other conditions. The variability observed in the covalent coupling method, likely due to secondary amines on the oligonucleotides affecting melting behavior, introduces potential inconsistencies in test results. Smoother melting curves achieved with non-covalent coupling suggest more consistent and predictable binding of target miRNAs to the microbeads. This translates directly into improved analytical sensitivity – meaning the ability to detect even low concentrations of miRNA biomarkers – and greater accuracy in quantification. For bioanalytical tests intended for clinical diagnostics or biomedical research, these improvements are crucial. Reliable detection of subtle changes in miRNA levels can be vital for early disease diagnosis, monitoring treatment response, or understanding disease progression. By optimizing the immobilization strategy on microbeads to ensure efficient and consistent hybridization, this study contributes to developing more dependable and sensitive bioanalytical tools that can ultimately advance our ability to diagnose and manage a wide range of diseases.

Astrid Honc-Gruber

@Astrid@fediscience.org last yr.

Today marks the conclusion of my internship at @tuberlin 🎓 I had an incredible research experience, thanks to my supervisor, Professor Mario Birkholz (see picture), and my advisors, Professor Anders Henriksson and Phillip Schrenk.

During this time, I learned about the innovative technology of silicon optical sensors 🔬💡 and developed as a researcher by enhancing my data collection methods 📊 and improving the experimental setup. ⚙️ I also honed my skills in interpreting numerical data 📈 and testing hypotheses.

@JLBe
#bioelectronic #microelectronic #biosensor

Stefan Rödiger

@pangolin last yr.

Great that you enjoyed your stay.

Stefan Rödiger boosted

Astrid Honc-Gruber

@Astrid@fediscience.org last yr.

@JLBe
#bioelectronic #microelectronic #biosensor